Mitochondrial peptide · Mitochondrial Open Reading Frame 12S c
≥99% HPLC per independent batch · the measured value of each batch is on its COA
Refrigerated at 2–8°C in our warehouse · lyophilized and stable during shipping
Receive it in 1 to 3 business days
If it is lost in transit, at no cost
| Purity | 99% HPLC (guaranteed minimum; the measured value of each batch is on its COA) |
| Storage | -20°C lyophilized · 2-8°C reconstituted |
| Presentation | Price | Per mg |
|---|---|---|
| 10 mg | $1,100 MXN | $110.00 MXN |
| 40 mg | $2,800 MXN | $70.00 MXN mejor precio |
MOTS-c is a 16-amino-acid peptide encoded by the mitochondrial genome (not the nuclear one), making it one of the few peptides of mitochondrial origin identified. It acts as a regulator of systemic metabolism and the cellular stress response, with properties studied in aging and metabolic resistance.
See the full technical sheet: mechanism, evidence and regulatory status ↓
The following research areas have been studied in preclinical models (in vitro and in vivo in animals). This information is for scientific reference only.
Chemical identity, studied mechanism, quality of the available evidence and regulatory status. Reference material; you do not need to read it to buy.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 1 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL recommended | 10,000 mcg/mL | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) | 10 IU (0.1 mL) |
| 2 mL | 5,000 mcg/mL | 5 IU (0.05 mL) | 10 IU (0.1 mL) | 20 IU (0.2 mL) |
| 3 mL | 3,333.33 mcg/mL | 7.5 IU (0.08 mL) | 15 IU (0.15 mL) | 30 IU (0.3 mL) |
| 5 mL | 2,000 mcg/mL | 12.5 IU (0.13 mL) | 25 IU (0.25 mL) | 50 IU (0.5 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 2 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL | 40,000 mcg/mL | 0.63 IU (0.01 mL) | 1.25 IU (0.01 mL) | 2.5 IU (0.03 mL) |
| 2 mL recommended | 20,000 mcg/mL | 1.25 IU (0.01 mL) | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) |
| 3 mL | 13,333.33 mcg/mL | 1.88 IU (0.02 mL) | 3.75 IU (0.04 mL) | 7.5 IU (0.08 mL) |
| 5 mL | 8,000 mcg/mL | 3.13 IU (0.03 mL) | 6.25 IU (0.06 mL) | 12.5 IU (0.13 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Need a different amount? Use the reconstitution calculator or see the full table by vial.
Current status: No regulatory approval. Under active FDA evaluation.
In Mexico, a research peptide is sold as a laboratory reagent (RUO, research use only). It is not a medicine: it has no COFEPRIS sanitary registration for human or veterinary use, it is not dispensed in pharmacies and it does not require a prescription, precisely because it is not sold to be administered to people. RUO labeling is not a commercial technicality; it is the product's regulatory category and defines what can and cannot legally be done with it. Since it is a domestic shipment, the order does not go through customs and is not subject to import procedures.
Regulatory framework reviewed in August 2026. See the full regulatory timeline, with the dates of each FDA decision between 2023 and 2026.
Compounds in the same category, with what sets each one apart and its entry price. Mechanism and cost are compared, not efficacy: there are no human trials that allow them to be ranked by outcome.
| Compound | What sets it apart | From |
|---|---|---|
| MOTS-c este producto | Mitochondrial peptide · Mitochondrial Open Reading Frame 12S c | $1,100 ($110/mg) |
| GHK-Cu | Gly-His-Lys tripeptide · Copper Peptide GHK-Cu | $800 ($16/mg) |
| Epitalon | Pineal regulatory tetrapeptide · Synthetic Epithalamin | $2,520 ($50/mg) |
| Thymalin (agotado) | Thymic peptide extract · Immunomodulator | $1,100 ($110/mg) |
Comparativa detallada: MOTS-c vs SS-31 →
MOTS-c is a 16-amino-acid peptide with a feature that sets it apart from everything else in this catalog: it is not encoded in the nuclear genome, but within the mitochondrial genome itself, in a short open reading frame located in the 12S ribosomal RNA gene. Its name is the acronym of that location: Mitochondrial Open reading frame of the Twelve S rRNA type-c.
It was identified in 2015 by Changhan Lee, Pinchas Cohen and colleagues at the University of Southern California, and published in Cell Metabolism. The finding had conceptual relevance beyond the compound: until then it was assumed that mitochondrial DNA encoded only thirteen respiratory chain proteins. MOTS-c, together with humanin discovered earlier in the 16S RNA, established the category of mitochondria-derived peptides, which act as retrograde signals from the organelle to the nucleus.
Also known as: Mitochondria-derived peptide (12S rRNA).
The described pathway is indirect and unusual. MOTS-c does not bind to a membrane receptor: it interferes with the folate cycle and with the de novo purine biosynthesis that depends on it. That interference causes AICAR, a metabolic intermediate, to accumulate, and AICAR phosphorylates and activates AMPK, the kinase that works as a sensor of the cell's energy state.
The original study reported a more than twentyfold increase in endogenous AICAR levels and consequent AMPK activation in HEK293 cells and in mouse skeletal muscle, which appears as the main target organ. Under metabolic stress, the peptide also translocates to the nucleus, where it participates in regulating genes with antioxidant response elements.
A physiological detail relevant to interpreting the literature: MOTS-c circulates in plasma, its levels decline with age in both plasma and muscle, and exercise raises them markedly. A study published in Nature Communications in 2021 reported in humans an increase of about twelvefold in skeletal muscle and 1.6-fold in circulation after exercise.
Route used in the studies: Subcutaneous (SC). It is given for documentation purposes, to interpret the literature; it is not an instruction for use.
The preclinical base is consistent and comes from independent groups, which distinguishes it favorably from other compounds on this list. In animal models, MOTS-c administration prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity.
That said, there is a distinction that is often lost when reading about this compound and it should be highlighted: it is one thing for endogenous MOTS-c to increase with exercise and be associated with a better metabolic profile, and another for exogenous MOTS-c administration to reproduce those effects in humans. The former is documented; the latter has not been established in controlled clinical trials, none of which have been published.
It is not approved in any country. It was placed in Category 2 of the FDA 503A list on September 29, 2023 and reviewed by the agency's advisory committee on July 23, 2026.
The following lines appear in the preclinical literature. They are listed for scientific reference only: they are not indications, efficacy claims or suggestions for use.
| Compound | Main difference |
|---|---|
| Humanina | The first mitochondria-derived peptide described, encoded in the 16S ribosomal RNA. Its literature focuses on neuronal and vascular cytoprotection, not on glucose metabolism. |
| 5-Amino-1MQ | It acts by inhibiting the NNMT enzyme, a completely different mechanism, although it is also studied in a metabolic context. |
The vial is delivered lyophilized, that is, as a dry powder obtained by freeze-drying. In that form it is stable and does not require a cold chain during transport: shipping does not compromise the material. On receipt, it is kept refrigerated between 2 and 8 °C, protected from light.
For the MOTS-c strengths, a reference reconstitution would be: el vial de 10 mg with 1 mL of bacteriostatic water queda a 10 mg/mL; el vial de 40 mg with 2 mL of bacteriostatic water queda a 20 mg/mL. The volume is not fixed — more water gives a more dilute solution with a larger measuring margin; less water concentrates it — and the choice depends on the working protocol.
The diluent is added slowly along the wall of the vial, never directly onto the powder, and left to rest for five to ten minutes. The vial is swirled gently until fully dissolved; shaking it hard subjects the peptide to mechanical stress that can denature it. Once reconstituted, it is kept refrigerated and is not frozen.
Bacteriostatic water contains 0.9% benzyl alcohol as a preservative, which allows multiple draws from the same vial. Plain sterile water has no preservative and is only suitable for immediate use. Signs of degradation to watch for: cloudy solution, visible particles, change in color or odor.
Because it is encoded within the mitochondrial genome rather than the nuclear one, which makes it a retrograde signal from the mitochondria to the rest of the cell. It belongs to the category of mitochondria-derived peptides, established in 2015 following its discovery.
Yes, the endogenous peptide. A 2021 study in Nature Communications reported in humans an increase of about twelvefold in skeletal muscle and 1.6-fold in circulation after exercise. It is important not to confuse that finding with exogenous administration of the peptide, whose effects in humans have not been established in controlled trials.
No. It is sold exclusively as a research-use-only (RUO) reagent, labeled as not fit for human consumption. It has no COFEPRIS sanitary registration and no approval from any other agency for human or veterinary use.
Every batch comes with a Certificate of Analysis issued by an independent laboratory, with the HPLC chromatogram, the purity percentage, the batch number and the date of analysis. It is included in the price and you can download it from the product page and from your account.
Shipping is express, 1 to 3 business days depending on the area, with a tracking number, to all 32 states. Since it is a domestic shipment sent from within Mexico, it does not go through customs: there are no holds or import procedures.
Lessons from the free certification that explain MOTS-c and its scientific context:
This compound has no reviews of its own yet. Below you can see what customers say about other products in the catalog: each card shows which one it refers to.
Super bien muy recomedado este laboratorio y llegan en 2 dias 🙏🏻 gracias seguire comprando con ellos
Es mi segunda vez que pido y estoy más que convencido de la excelente calidad y servicio de su equipo... ampliamente recomendables
Empaque excelente, Recibir tu pedido con agua Bac3ml es lo mejor. Entrega en 3 días max.
Me sorprendió la atención y la presentación, llegó a tiempo y muy bien empacado y con su BAC water, absolutamente recomendables y también tiene su guía de preparación y uso que te llega con dos QR en tu paquete
Excelente servicio, muy amables, siempre he recibido mis productos en tiempo y forma, llegan muy bien protegidos y el producto me ha funcionado de maravilla
el servicio desde el primer contacto excelente el envio rapido y todo a la perfecccion los peptidos una maravilla
Excelente servicio, muy amables, muy el paquete llegó en tiempo y forma, muy bien empaquetado y producto de calidad.
Es la 3a vez que compro y todo va bien ! Los empaques de lujo y el seguimiento igual ! Éxitos
Excelente servicio, muy seguro, el péptico llegó perfectamente empacado, llego en el tiempo indicado
✉️ We request reviews automatically by email after purchase.
Technical assistant · AI
