Pineal regulatory tetrapeptide · Synthetic Epithalamin
≥99% HPLC per independent batch · the measured value of each batch is on its COA
Refrigerated at 2–8°C in our warehouse · lyophilized and stable during shipping
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| Molecular class | Bioregulatory tetrapeptide |
| Sequence | Ala-Glu-Asp-Gly (AEDG) |
| Formula | C14H22N4O9 |
| Molecular weight | 390.35 g/mol |
| CAS | 307297-39-8 |
| Purity | 99% HPLC (guaranteed minimum; the measured value of each batch is on its COA) |
| Storage | -20°C lyophilized · 2-8°C reconstituted |
Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide analog of Epithalamin, a natural extract of the pineal gland. It was developed by the Saint Petersburg Institute of Gerontology and has been extensively investigated in models of aging, circadian cycle and telomere regulation.
See the full technical sheet: mechanism, evidence and regulatory status ↓
The following research areas have been studied in preclinical models (in vitro and in vivo in animals). This information is for scientific reference only.
Chemical identity, studied mechanism, quality of the available evidence and regulatory status. Reference material; you do not need to read it to buy.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 2 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL | 50,000 mcg/mL | 0.5 IU (0.01 mL) | 1 IU (0.01 mL) | 2 IU (0.02 mL) |
| 2 mL recommended | 25,000 mcg/mL | 1 IU (0.01 mL) | 2 IU (0.02 mL) | 4 IU (0.04 mL) |
| 3 mL | 16,666.67 mcg/mL | 1.5 IU (0.02 mL) | 3 IU (0.03 mL) | 6 IU (0.06 mL) |
| 5 mL | 10,000 mcg/mL | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) | 10 IU (0.1 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Need a different amount? Use the reconstitution calculator or see the full table by vial.
Compounds in the same category, with what sets each one apart and its entry price. Mechanism and cost are compared, not efficacy: there are no human trials that allow them to be ranked by outcome.
| Compound | What sets it apart | From |
|---|---|---|
| Epitalon este producto | Pineal regulatory tetrapeptide · Synthetic Epithalamin | $2,520 ($50/mg) |
| Pinealon (agotado) | Glu-Asp-Arg tripeptide · Pineal regulator | $1,100 ($110/mg) |
| GHK-Cu | Gly-His-Lys tripeptide · Copper Peptide GHK-Cu | $800 ($16/mg) |
| MOTS-c | Mitochondrial peptide · Mitochondrial Open Reading Frame 12S c | $1,100 ($110/mg) |
Comparativa detallada: Epitalon vs Pinealon →
Epitalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, designed as a shortened synthetic version of epithalamin, a pineal gland extract studied in the Soviet gerontological school.
Its development is attributed to Vladimir Khavinson's group in Saint Petersburg, as part of a line of work on peptide bioregulators and aging that began in the 1980s.
In terms of chemical identity, it is classified as Bioregulatory tetrapeptide, its CAS number is 307297-39-8, its molecular weight is 390.35 g/mol. These identifiers are what allow the material received to be checked against the batch Certificate of Analysis.
Also known as: Synthetic Epithalamin · Ala-Glu-Asp-Gly tetrapeptide.
The central hypothesis of the available literature is the modulation of telomerase activity and, through that route, of telomere length in cell cultures. Effects on melatonin secretion and circadian rhythms in animal models have also been reported.
Route used in the studies: Subcutaneous (SC) or intramuscular. It is given for documentation purposes, to interpret the literature; it is not an instruction for use.
This is a compound where caution about the quality of the evidence must be explicit. The literature is highly concentrated in a single research group and in a publication tradition with reporting standards different from today's; independent replication is scarce.
The relationship between telomerase activity and longevity is also an open question in the biology of aging, not an established fact, and it should not be presented as such.
It is not approved in any country. It was placed in Category 2 of the 503A list on September 29, 2023 and reviewed by the FDA advisory committee on July 24, 2026.
Reference: Literature on peptide bioregulators (Khavinson and colleagues).
The following lines appear in the preclinical literature. They are listed for scientific reference only: they are not indications, efficacy claims or suggestions for use.
The vial is delivered lyophilized, that is, as a dry powder obtained by freeze-drying. In that form it is stable and does not require a cold chain during transport: shipping does not compromise the material. On receipt, it is kept refrigerated between 2 and 8 °C, protected from light.
For the Epitalon strengths, a reference reconstitution would be: el vial de 50 mg with 2 mL of bacteriostatic water queda a 25 mg/mL. The volume is not fixed — more water gives a more dilute solution with a larger measuring margin; less water concentrates it — and the choice depends on the working protocol.
The diluent is added slowly along the wall of the vial, never directly onto the powder, and left to rest for five to ten minutes. The vial is swirled gently until fully dissolved; shaking it hard subjects the peptide to mechanical stress that can denature it. Once reconstituted, it is kept refrigerated and is not frozen.
Bacteriostatic water contains 0.9% benzyl alcohol as a preservative, which allows multiple draws from the same vial. Plain sterile water has no preservative and is only suitable for immediate use. Signs of degradation to watch for: cloudy solution, visible particles, change in color or odor.
No. It is sold exclusively as a research-use-only (RUO) reagent, labeled as not fit for human consumption. It has no COFEPRIS sanitary registration and no approval from any other agency for human or veterinary use.
Every batch comes with a Certificate of Analysis issued by an independent laboratory, with the HPLC chromatogram, the purity percentage, the batch number and the date of analysis. It is included in the price and you can download it from the product page and from your account.
Shipping is express, 1 to 3 business days depending on the area, with a tracking number, to all 32 states. Since it is a domestic shipment sent from within Mexico, it does not go through customs: there are no holds or import procedures.
Lessons from the free certification that explain Epitalon and its scientific context:
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Super bien muy recomedado este laboratorio y llegan en 2 dias 🙏🏻 gracias seguire comprando con ellos
Es mi segunda vez que pido y estoy más que convencido de la excelente calidad y servicio de su equipo... ampliamente recomendables
Empaque excelente, Recibir tu pedido con agua Bac3ml es lo mejor. Entrega en 3 días max.
Me sorprendió la atención y la presentación, llegó a tiempo y muy bien empacado y con su BAC water, absolutamente recomendables y también tiene su guía de preparación y uso que te llega con dos QR en tu paquete
Excelente servicio, muy amables, siempre he recibido mis productos en tiempo y forma, llegan muy bien protegidos y el producto me ha funcionado de maravilla
el servicio desde el primer contacto excelente el envio rapido y todo a la perfecccion los peptidos una maravilla
Excelente servicio, muy amables, muy el paquete llegó en tiempo y forma, muy bien empaquetado y producto de calidad.
Es la 3a vez que compro y todo va bien ! Los empaques de lujo y el seguimiento igual ! Éxitos
Excelente servicio, muy seguro, el péptico llegó perfectamente empacado, llego en el tiempo indicado
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