Triple GLP-1/GIP/Glucagon agonist · LY3437943
≥99% HPLC per independent batch · the measured value of each batch is on its COA
Refrigerated at 2–8°C in our warehouse · lyophilized and stable during shipping
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If it is lost in transit, at no cost
| Molecular class | Triple GIP/GLP-1/glucagon agonist (39 amino acids) |
| CAS | 2381089-83-2 |
| Purity | 99% HPLC (guaranteed minimum; the measured value of each batch is on its COA) |
| Storage | -20°C lyophilized · 2-8°C reconstituted |
| Presentation | Price | Per mg |
|---|---|---|
| 10 mg | $1,400 MXN | $140.00 MXN |
| 20 mg | $2,100 MXN | $105.00 MXN |
| 30 mg | $3,000 MXN | $100.00 MXN |
| 40 mg | $3,600 MXN | $90.00 MXN |
| 50 mg | $4,100 MXN | $82.00 MXN |
| 60 mg | $4,600 MXN | $76.67 MXN mejor precio |
You can buy Retatrutide in Mexico for research at NeoPeptidos. Retatrutide is a synthetic peptide that acts as a triple agonist of the GLP-1, GIP and Glucagon (GcgR) receptors. Its triple profile gives it unique metabolic properties studied in obesity and dyslipidemia models, with especially notable results in adipose tissue reduction.
See the full technical sheet: mechanism, evidence and regulatory status ↓
The following research areas have been studied in preclinical models (in vitro and in vivo in animals). This information is for scientific reference only.
Chemical identity, studied mechanism, quality of the available evidence and regulatory status. Reference material; you do not need to read it to buy.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 1 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL recommended | 10,000 mcg/mL | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) | 10 IU (0.1 mL) |
| 2 mL | 5,000 mcg/mL | 5 IU (0.05 mL) | 10 IU (0.1 mL) | 20 IU (0.2 mL) |
| 3 mL | 3,333.33 mcg/mL | 7.5 IU (0.08 mL) | 15 IU (0.15 mL) | 30 IU (0.3 mL) |
| 5 mL | 2,000 mcg/mL | 12.5 IU (0.13 mL) | 25 IU (0.25 mL) | 50 IU (0.5 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 2 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL | 20,000 mcg/mL | 1.25 IU (0.01 mL) | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) |
| 2 mL recommended | 10,000 mcg/mL | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) | 10 IU (0.1 mL) |
| 3 mL | 6,666.67 mcg/mL | 3.75 IU (0.04 mL) | 7.5 IU (0.08 mL) | 15 IU (0.15 mL) |
| 5 mL | 4,000 mcg/mL | 6.25 IU (0.06 mL) | 12.5 IU (0.13 mL) | 25 IU (0.25 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 2 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL | 30,000 mcg/mL | 0.83 IU (0.01 mL) | 1.67 IU (0.02 mL) | 3.33 IU (0.03 mL) |
| 2 mL recommended | 15,000 mcg/mL | 1.67 IU (0.02 mL) | 3.33 IU (0.03 mL) | 6.67 IU (0.07 mL) |
| 3 mL | 10,000 mcg/mL | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) | 10 IU (0.1 mL) |
| 5 mL | 6,000 mcg/mL | 4.17 IU (0.04 mL) | 8.33 IU (0.08 mL) | 16.67 IU (0.17 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 2 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL | 40,000 mcg/mL | 0.63 IU (0.01 mL) | 1.25 IU (0.01 mL) | 2.5 IU (0.03 mL) |
| 2 mL recommended | 20,000 mcg/mL | 1.25 IU (0.01 mL) | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) |
| 3 mL | 13,333.33 mcg/mL | 1.88 IU (0.02 mL) | 3.75 IU (0.04 mL) | 7.5 IU (0.08 mL) |
| 5 mL | 8,000 mcg/mL | 3.13 IU (0.03 mL) | 6.25 IU (0.06 mL) | 12.5 IU (0.13 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 2 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL | 50,000 mcg/mL | 0.5 IU (0.01 mL) | 1 IU (0.01 mL) | 2 IU (0.02 mL) |
| 2 mL recommended | 25,000 mcg/mL | 1 IU (0.01 mL) | 2 IU (0.02 mL) | 4 IU (0.04 mL) |
| 3 mL | 16,666.67 mcg/mL | 1.5 IU (0.02 mL) | 3 IU (0.03 mL) | 6 IU (0.06 mL) |
| 5 mL | 10,000 mcg/mL | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) | 10 IU (0.1 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 3 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL | 60,000 mcg/mL | 0.42 IU (0 mL) | 0.83 IU (0.01 mL) | 1.67 IU (0.02 mL) |
| 2 mL | 30,000 mcg/mL | 0.83 IU (0.01 mL) | 1.67 IU (0.02 mL) | 3.33 IU (0.03 mL) |
| 3 mL recommended | 20,000 mcg/mL | 1.25 IU (0.01 mL) | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) |
| 5 mL | 12,000 mcg/mL | 2.08 IU (0.02 mL) | 4.17 IU (0.04 mL) | 8.33 IU (0.08 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Need a different amount? Use the reconstitution calculator or see the full table by vial.
Current status: A molecule in clinical research. Not approved in any country.
In Mexico, a research peptide is sold as a laboratory reagent (RUO, research use only). It is not a medicine: it has no COFEPRIS sanitary registration for human or veterinary use, it is not dispensed in pharmacies and it does not require a prescription, precisely because it is not sold to be administered to people. RUO labeling is not a commercial technicality; it is the product's regulatory category and defines what can and cannot legally be done with it. Since it is a domestic shipment, the order does not go through customs and is not subject to import procedures.
Since it has not completed its clinical development, its long-term safety profile in humans has not been established. It is a research compound in the most literal sense.
Regulatory framework reviewed in August 2026. See the full regulatory timeline, with the dates of each FDA decision between 2023 and 2026.
Compounds in the same category, with what sets each one apart and its entry price. Mechanism and cost are compared, not efficacy: there are no human trials that allow them to be ranked by outcome.
| Compound | What sets it apart | From |
|---|---|---|
| Retatrutide este producto | Triple GLP-1/GIP/Glucagon agonist · LY3437943 | $1,400 ($140/mg) |
| Tirzepatide | Dual GLP-1/GIP agonist · Mounjaro® INN | $1,300 ($130/mg) |
| Semaglutide | Long-acting GLP-1 agonist · Ozempic® / Wegovy® INN | $1,000 ($100/mg) |
| Cagrilintide | Long-acting amylin analog · AM833 | $1,800 ($180/mg) |
Comparativa detallada: Semaglutida vs Tirzepatida vs Retatrutida →
Retatrutide is a synthetic 39-amino-acid peptide that acts as a triple agonist on the GIP, GLP-1 and glucagon receptors. It is a molecule in clinical development, not approved in any country.
Developed by its originator laboratory as a continuation of the multiple-incretin agonist line, after semaglutide (mono) and tirzepatide (dual). The interest in adding glucagon receptor agonism lies in its role in energy expenditure and hepatic lipid metabolism.
In terms of chemical identity, it is classified as Triple GIP/GLP-1/glucagon agonist (39 amino acids), its CAS number is 2381089-83-2. These identifiers are what allow the material received to be checked against the batch Certificate of Analysis.
Also known as: LY3437943 · triple GLP-1/GIP/Glucagon agonist.
It combines three activities. The GLP-1 component provides glucose-dependent insulin secretion, slower gastric emptying and satiety; the GIP component adds the second incretin pathway; and the glucagon component, seemingly counterintuitive, is associated with increased energy expenditure and mobilization of hepatic lipids.
The pharmacological challenge for this class of molecules is the balance among the three activities: isolated glucagon agonism would tend to raise blood glucose, and it is the concurrent incretin action that offsets that effect. That balance is precisely what ongoing studies are characterizing.
Route used in the studies: Subcutaneous (SC), weekly. It is given for documentation purposes, to interpret the literature; it is not an instruction for use.
It is important to place it correctly relative to semaglutide and tirzepatide, with which it is often grouped: those are approved medicines and this one is not approved in any country. It is in clinical development and its long-term safety profile in humans has not been established.
That makes it a research compound in the most literal sense of the term. There is no registered pharmaceutical version to compare it with, and the publicly available information comes from ongoing trials, not from an approved label.
Reference: Jastreboff et al., NEJM 2023 (Phase 2).
The following lines appear in the preclinical literature. They are listed for scientific reference only: they are not indications, efficacy claims or suggestions for use.
| Compound | Main difference |
|---|---|
| Tirzepatide | Dual GIP/GLP-1 agonist, without a glucagon component. Unlike retatrutide, it is approved and registered in Mexico. |
| Semaglutide | Single GLP-1 agonist, also approved and registered in Mexico. |
| Survodutide | Dual GLP-1/glucagon agonist, without a GIP component. Also under investigation. |
The vial is delivered lyophilized, that is, as a dry powder obtained by freeze-drying. In that form it is stable and does not require a cold chain during transport: shipping does not compromise the material. On receipt, it is kept refrigerated between 2 and 8 °C, protected from light.
For the Retatrutide strengths, a reference reconstitution would be: el vial de 10 mg with 1 mL of bacteriostatic water queda a 10 mg/mL; el vial de 20 mg with 2 mL of bacteriostatic water queda a 10 mg/mL; el vial de 30 mg with 2 mL of bacteriostatic water queda a 15 mg/mL; el vial de 40 mg with 2 mL of bacteriostatic water queda a 20 mg/mL; el vial de 50 mg with 2 mL of bacteriostatic water queda a 25 mg/mL; el vial de 60 mg with 3 mL of bacteriostatic water queda a 20 mg/mL. The volume is not fixed — more water gives a more dilute solution with a larger measuring margin; less water concentrates it — and the choice depends on the working protocol.
The diluent is added slowly along the wall of the vial, never directly onto the powder, and left to rest for five to ten minutes. The vial is swirled gently until fully dissolved; shaking it hard subjects the peptide to mechanical stress that can denature it. Once reconstituted, it is kept refrigerated and is not frozen.
Bacteriostatic water contains 0.9% benzyl alcohol as a preservative, which allows multiple draws from the same vial. Plain sterile water has no preservative and is only suitable for immediate use. Signs of degradation to watch for: cloudy solution, visible particles, change in color or odor.
No. Semaglutide and tirzepatide are approved medicines registered in Mexico; retatrutide is not approved in any country and remains in clinical development. It is a substantial difference that should not be overlooked when grouping them.
No. It is sold exclusively as a research-use-only (RUO) reagent, labeled as not fit for human consumption. It has no COFEPRIS sanitary registration and no approval from any other agency for human or veterinary use.
Every batch comes with a Certificate of Analysis issued by an independent laboratory, with the HPLC chromatogram, the purity percentage, the batch number and the date of analysis. It is included in the price and you can download it from the product page and from your account.
Shipping is express, 1 to 3 business days depending on the area, with a tracking number, to all 32 states. Since it is a domestic shipment sent from within Mexico, it does not go through customs: there are no holds or import procedures.
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