GHRH analog · Growth hormone-releasing factor
≥99% HPLC per independent batch · the measured value of each batch is on its COA
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| Molecular class | GHRH analog (44 amino acids) |
| Molecular weight | 5135.9 g/mol |
| CAS | 218949-48-5 |
| Purity | 99% HPLC (guaranteed minimum; the measured value of each batch is on its COA) |
| Storage | -20°C lyophilized · 2-8°C reconstituted |
| Presentation | Price | Per mg |
|---|---|---|
| 10 mg | $2,000 MXN | $200.00 MXN |
| 20 mg | $3,200 MXN | $160.00 MXN mejor precio |
Tesamorelin is a 44-amino-acid synthetic analog of growth hormone-releasing hormone (GHRH), modified with a trans-3-hexenoyl group to increase its stability. It stimulates pulsatile GH secretion by the pituitary, preserving the feedback axis.
See the full technical sheet: mechanism, evidence and regulatory status ↓
The following research areas have been studied in preclinical models (in vitro and in vivo in animals). This information is for scientific reference only.
Chemical identity, studied mechanism, quality of the available evidence and regulatory status. Reference material; you do not need to read it to buy.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 1 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL recommended | 10,000 mcg/mL | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) | 10 IU (0.1 mL) |
| 2 mL | 5,000 mcg/mL | 5 IU (0.05 mL) | 10 IU (0.1 mL) | 20 IU (0.2 mL) |
| 3 mL | 3,333.33 mcg/mL | 7.5 IU (0.08 mL) | 15 IU (0.15 mL) | 30 IU (0.3 mL) |
| 5 mL | 2,000 mcg/mL | 12.5 IU (0.13 mL) | 25 IU (0.25 mL) | 50 IU (0.5 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 2 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL | 20,000 mcg/mL | 1.25 IU (0.01 mL) | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) |
| 2 mL recommended | 10,000 mcg/mL | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) | 10 IU (0.1 mL) |
| 3 mL | 6,666.67 mcg/mL | 3.75 IU (0.04 mL) | 7.5 IU (0.08 mL) | 15 IU (0.15 mL) |
| 5 mL | 4,000 mcg/mL | 6.25 IU (0.06 mL) | 12.5 IU (0.13 mL) | 25 IU (0.25 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Need a different amount? Use the reconstitution calculator or see the full table by vial.
Current status: A medicine approved by the FDA for a specific indication; the RUO material is not that medicine.
In Mexico, a research peptide is sold as a laboratory reagent (RUO, research use only). It is not a medicine: it has no COFEPRIS sanitary registration for human or veterinary use, it is not dispensed in pharmacies and it does not require a prescription, precisely because it is not sold to be administered to people. RUO labeling is not a commercial technicality; it is the product's regulatory category and defines what can and cannot legally be done with it. Since it is a domestic shipment, the order does not go through customs and is not subject to import procedures.
The fact that the molecule is approved as a medicine in some country does not turn the research reagent into that medicine. An RUO product is not manufactured under the pharmaceutical standards that apply to a prescription drug, and it is not authorized for human use.
Regulatory framework reviewed in August 2026. See the full regulatory timeline, with the dates of each FDA decision between 2023 and 2026.
Compounds in the same category, with what sets each one apart and its entry price. Mechanism and cost are compared, not efficacy: there are no human trials that allow them to be ranked by outcome.
| Compound | What sets it apart | From |
|---|---|---|
| Tesamorelin este producto | GHRH analog · Growth hormone-releasing factor | $2,000 ($200/mg) |
| CJC-1295 DAC | GHRH analog with Drug Affinity Complex · Extended half-life | $1,300 ($260/mg) |
| CJC-1295 + Ipamorelin | GHRH + Secretagogue stack · Synergistic combination | $2,100 ($210/mg) |
| Ipamorelin | Selective GH secretagogue · GHRP pentapeptide | $1,400 ($140/mg) |
Comparativa detallada: Tesamorelina vs CJC-1295 →
Tesamorelin is a stabilized synthetic analog of growth hormone-releasing hormone (GHRH) that reproduces the full 44-amino-acid sequence of human GHRH with a trans-3-hexenoyl group attached to the tyrosine at the amino terminus. It is the only GHRH analog that has achieved and maintains an active regulatory approval.
It was developed by Theratechnologies in Montreal. Native GHRH is rapidly degraded by the DPP-4 enzyme and other proteases, which limited its usefulness; the hexenoyl modification protects that cleavage site and preserves activity at the receptor. The FDA approved it on November 10, 2010 under the brand Egrifta, as a new molecular entity.
In terms of chemical identity, it is classified as GHRH analog (44 amino acids), its CAS number is 218949-48-5, its molecular weight is 5135.9 g/mol. These identifiers are what allow the material received to be checked against the batch Certificate of Analysis.
Also known as: GHRH analog (Egrifta®).
It acts on the GHRH receptor in the somatotroph cells of the anterior pituitary, a Gs protein-coupled receptor. Its activation raises intracellular cyclic AMP and stimulates the synthesis and release of endogenous growth hormone, which in turn drives hepatic IGF-1 production.
The difference from direct administration of growth hormone is conceptual and not minor: by acting one step higher in the axis, the pulsatile secretion pattern and the negative feedback by somatostatin are preserved. The regulatory documentation describes a short elimination half-life —on the order of 18 to 37 minutes depending on single or repeated dosing— with a biological signal that persists considerably longer than the molecule's own presence in plasma.
Route used in the studies: Subcutaneous (SC). It is given for documentation purposes, to interpret the literature; it is not an instruction for use.
This is the compound with the strongest clinical base in the entire catalog, and also the one where it matters most to read precisely what exactly was approved. The registration program included two phase 3 trials with 816 adults with HIV and lipodystrophy; 543 received the drug during a 26-week placebo-controlled period, with visceral adipose tissue measured by computed tomography as the primary endpoint. The reported reduction in visceral fat was around 15-18% at 26 weeks.
The approved indication is a single, narrow one: reduction of excess abdominal fat in adult patients with HIV and lipodystrophy. The FDA-approved label itself explicitly warns that the product is not indicated for weight management, and that long-term cardiovascular safety has not been established. The FDA's internal review went even further and recorded that approving on the basis of visceral fat reduction in that specific population does not constitute an endorsement of that endpoint as a valid criterion for other, more prevalent conditions.
Two warnings from the regulatory file are also worth keeping in mind: by inducing growth hormone release it raises IGF-1 levels, whose effect on the development or progression of neoplasms has not been determined, and for that reason the label contraindicates its use in the presence of active malignancy.
And the usual distinction, which is especially relevant here because there is a real medicine to compare it with: the material in this catalog is a research reagent, not Egrifta. They share the molecule, but not manufacturing standards, impurity and stability controls, primary packaging, approved labeling or a responsible marketing authorization holder. Anyone who needs the medicine should see a doctor.
The following lines appear in the preclinical literature. They are listed for scientific reference only: they are not indications, efficacy claims or suggestions for use.
Within the family of compounds acting on the growth hormone axis, tesamorelin holds a unique position: it is the only one with an active regulatory approval.
| Compound | Main difference |
|---|---|
| CJC-1295 | Also a GHRH analog, but not approved in any country. Tesamorelin reproduces the full 44-amino-acid GHRH; CJC-1295 is based on the 1-29 fragment. |
| Ipamorelin | It acts on the ghrelin receptor, not on the GHRH receptor. A different pathway, with no regulatory approval. |
| Sermorelin | A GHRH analog based on the 1-29 fragment. It was once approved as Geref, but its commercial production was discontinued. |
The vial is delivered lyophilized, that is, as a dry powder obtained by freeze-drying. In that form it is stable and does not require a cold chain during transport: shipping does not compromise the material. On receipt, it is kept refrigerated between 2 and 8 °C, protected from light.
For the Tesamorelin strengths, a reference reconstitution would be: el vial de 10 mg with 1 mL of bacteriostatic water queda a 10 mg/mL; el vial de 20 mg with 2 mL of bacteriostatic water queda a 10 mg/mL. The volume is not fixed — more water gives a more dilute solution with a larger measuring margin; less water concentrates it — and the choice depends on the working protocol.
The diluent is added slowly along the wall of the vial, never directly onto the powder, and left to rest for five to ten minutes. The vial is swirled gently until fully dissolved; shaking it hard subjects the peptide to mechanical stress that can denature it. Once reconstituted, it is kept refrigerated and is not frozen.
Bacteriostatic water contains 0.9% benzyl alcohol as a preservative, which allows multiple draws from the same vial. Plain sterile water has no preservative and is only suitable for immediate use. Signs of degradation to watch for: cloudy solution, visible particles, change in color or odor.
The FDA-approved label expressly states that the product is not indicated for weight management. Its only approved indication is the reduction of excess abdominal fat in adults with HIV and lipodystrophy, and its documented effect is on visceral fat specifically, not on total body weight.
Because it is the only GHRH analog with active FDA approval. Sermorelin was once approved as Geref but was commercially discontinued, and compounds such as CJC-1295 or ipamorelin have never been approved in any country.
It acts one step higher in the axis: it stimulates the pituitary to release its own hormone instead of supplying it from outside. That preserves the pulsatile secretion pattern and the physiological feedback by somatostatin, which direct exogenous administration suppresses.
No. It is sold exclusively as a research-use-only (RUO) reagent, labeled as not fit for human consumption. It has no COFEPRIS sanitary registration and no approval from any other agency for human or veterinary use.
Every batch comes with a Certificate of Analysis issued by an independent laboratory, with the HPLC chromatogram, the purity percentage, the batch number and the date of analysis. It is included in the price and you can download it from the product page and from your account.
Shipping is express, 1 to 3 business days depending on the area, with a tracking number, to all 32 states. Since it is a domestic shipment sent from within Mexico, it does not go through customs: there are no holds or import procedures.
Lessons from the free certification that explain Tesamorelin and its scientific context:
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