Thymosin Beta-4 fragment · Tβ4 Acetate
≥99% HPLC per independent batch · the measured value of each batch is on its COA
Refrigerated at 2–8°C in our warehouse · lyophilized and stable during shipping
Receive it in 1 to 3 business days
If it is lost in transit, at no cost
| Molecular class | Acetylated heptapeptide |
| Sequence | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (fragment 17–23 of thymosin β4) |
| Formula | C33H58N10O13 |
| Molecular weight | 794.90 g/mol |
| CAS | 885340-08-9 |
| Purity | 99% HPLC (guaranteed minimum; the measured value of each batch is on its COA) |
| Storage | -20°C lyophilized · 2-8°C reconstituted |
TB-500 is the Ac-SDKP sequence fragment of Thymosin Beta-4 (Tβ4), an endogenous protein involved in actin regulation. This fragment concentrates the cell migration, tissue repair and inflammatory modulation properties of full Tβ4 in a smaller, more stable peptide.
See the full technical sheet: mechanism, evidence and regulatory status ↓
The following research areas have been studied in preclinical models (in vitro and in vivo in animals). This information is for scientific reference only.
Chemical identity, studied mechanism, quality of the available evidence and regulatory status. Reference material; you do not need to read it to buy.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 1 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL recommended | 10,000 mcg/mL | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) | 10 IU (0.1 mL) |
| 2 mL | 5,000 mcg/mL | 5 IU (0.05 mL) | 10 IU (0.1 mL) | 20 IU (0.2 mL) |
| 3 mL | 3,333.33 mcg/mL | 7.5 IU (0.08 mL) | 15 IU (0.15 mL) | 30 IU (0.3 mL) |
| 5 mL | 2,000 mcg/mL | 12.5 IU (0.13 mL) | 25 IU (0.25 mL) | 50 IU (0.5 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Need a different amount? Use the reconstitution calculator or see the full table by vial.
Current status: No regulatory approval. Under active FDA evaluation.
In Mexico, a research peptide is sold as a laboratory reagent (RUO, research use only). It is not a medicine: it has no COFEPRIS sanitary registration for human or veterinary use, it is not dispensed in pharmacies and it does not require a prescription, precisely because it is not sold to be administered to people. RUO labeling is not a commercial technicality; it is the product's regulatory category and defines what can and cannot legally be done with it. Since it is a domestic shipment, the order does not go through customs and is not subject to import procedures.
TB-500 corresponds to the actin-binding motif of thymosin beta-4, not to the full protein. It is a distinction worth keeping in mind when reading literature that refers to "thymosin beta-4".
Regulatory framework reviewed in August 2026. See the full regulatory timeline, with the dates of each FDA decision between 2023 and 2026.
Compounds in the same category, with what sets each one apart and its entry price. Mechanism and cost are compared, not efficacy: there are no human trials that allow them to be ranked by outcome.
| Compound | What sets it apart | From |
|---|---|---|
| TB-500 este producto | Thymosin Beta-4 fragment · Tβ4 Acetate | $1,100 ($110/mg) |
| BPC-157 | Body Protection Compound · Gastric pentadecapeptide | $1,200 ($120/mg) |
| BPC + TB Combo | Synergistic repair stack · Wolverine Stack | $2,000 ($100/mg) |
| GLOW | BPC-157 + GHK-Cu + TB-500 · Triple repair stack | $2,800 ($40/mg) |
Comparativa detallada: BPC-157 vs TB-500 →
TB-500 is an acetylated heptapeptide with the sequence Ac-LKKTETQ, which corresponds to the actin-binding motif of thymosin beta-4. Precision matters: TB-500 is not thymosin beta-4, but the seven-amino-acid fragment described as responsible for much of its activity.
Thymosin beta-4 is a natural 43-amino-acid protein, present in virtually all body tissues and fluids, whose main function is to sequester G-actin and regulate cytoskeletal polymerization. TB-500 was developed as a shortened synthetic version of that active domain, easier to produce and more stable.
In terms of chemical identity, it is classified as Acetylated heptapeptide, its CAS number is 885340-08-9, its molecular weight is 794.90 g/mol. These identifiers are what allow the material received to be checked against the batch Certificate of Analysis.
Also known as: Thymosin Beta-4 fragment (Tβ4 acetate).
The described mechanism starts with binding to G-actin. By sequestering actin monomers, thymosin beta-4 and its active fragment modulate the balance between free and polymerized actin, which is what governs cell migration. In repair models, that modulation is associated with greater mobility of endothelial cells and keratinocytes toward the injury site.
The angiogenic and remodeling lines described in the literature derive from that migratory capacity: formation of vascular structures and reorganization of the extracellular matrix. Unlike BPC-157, whose literature describes markedly local effects, TB-500 has been studied with a more systemic distribution profile, which explains why both appear combined in research designs on recovery.
Route used in the studies: Subcutaneous (SC) or intramuscular. It is given for documentation purposes, to interpret the literature; it is not an instruction for use.
The evidence on full-length thymosin beta-4 is considerably stronger than that on the TB-500 fragment, and they should not be confused when reading the literature: much of what is cited in support of TB-500 actually corresponds to studies with the whole protein.
Thymosin beta-4 reached human clinical trials for ophthalmological and dermatological indications. TB-500 as such has no published controlled clinical trials and is not approved by any regulatory agency.
In the United States it was placed in Category 2 of the 503A list on September 29, 2023 under the name “Thymosin Beta-4, Fragment (LKKTETQ)”, removed from that category in April 2026 and reviewed by the FDA advisory committee on July 23, 2026. As in the other cases, those moves are steps in an administrative procedure on compounding, not approvals.
Reference: Preclinical and veterinary studies of thymosin β4.
The following lines appear in the preclinical literature. They are listed for scientific reference only: they are not indications, efficacy claims or suggestions for use.
| Compound | Main difference |
|---|---|
| BPC-157 | It acts on VEGFR2 and nitric oxide signaling, with literature focused on local effects, mainly gastrointestinal and tendon-related. TB-500 acts on the actin cytoskeleton with a more systemic profile. |
| Mezcla BPC-157 + TB-500 | It brings both mechanisms together in one vial. Since they are two separate molecules, it has no single chemical identity. |
The vial is delivered lyophilized, that is, as a dry powder obtained by freeze-drying. In that form it is stable and does not require a cold chain during transport: shipping does not compromise the material. On receipt, it is kept refrigerated between 2 and 8 °C, protected from light.
For the TB-500 strengths, a reference reconstitution would be: el vial de 10 mg with 1 mL of bacteriostatic water queda a 10 mg/mL. The volume is not fixed — more water gives a more dilute solution with a larger measuring margin; less water concentrates it — and the choice depends on the working protocol.
The diluent is added slowly along the wall of the vial, never directly onto the powder, and left to rest for five to ten minutes. The vial is swirled gently until fully dissolved; shaking it hard subjects the peptide to mechanical stress that can denature it. Once reconstituted, it is kept refrigerated and is not frozen.
Bacteriostatic water contains 0.9% benzyl alcohol as a preservative, which allows multiple draws from the same vial. Plain sterile water has no preservative and is only suitable for immediate use. Signs of degradation to watch for: cloudy solution, visible particles, change in color or odor.
No. Thymosin beta-4 is a 43-amino-acid protein; TB-500 is the acetylated seven-amino-acid fragment (Ac-LKKTETQ) corresponding to its actin-binding motif. The distinction matters when reading the literature, because many studies cited in support of TB-500 were done with the full protein.
No. It is sold exclusively as a research-use-only (RUO) reagent, labeled as not fit for human consumption. It has no COFEPRIS sanitary registration and no approval from any other agency for human or veterinary use.
Every batch comes with a Certificate of Analysis issued by an independent laboratory, with the HPLC chromatogram, the purity percentage, the batch number and the date of analysis. It is included in the price and you can download it from the product page and from your account.
Shipping is express, 1 to 3 business days depending on the area, with a tracking number, to all 32 states. Since it is a domestic shipment sent from within Mexico, it does not go through customs: there are no holds or import procedures.
Lessons from the free certification that explain TB-500 and its scientific context:
This compound has no reviews of its own yet. Below you can see what customers say about other products in the catalog: each card shows which one it refers to.
Super bien muy recomedado este laboratorio y llegan en 2 dias 🙏🏻 gracias seguire comprando con ellos
Es mi segunda vez que pido y estoy más que convencido de la excelente calidad y servicio de su equipo... ampliamente recomendables
Empaque excelente, Recibir tu pedido con agua Bac3ml es lo mejor. Entrega en 3 días max.
Me sorprendió la atención y la presentación, llegó a tiempo y muy bien empacado y con su BAC water, absolutamente recomendables y también tiene su guía de preparación y uso que te llega con dos QR en tu paquete
Excelente servicio, muy amables, siempre he recibido mis productos en tiempo y forma, llegan muy bien protegidos y el producto me ha funcionado de maravilla
el servicio desde el primer contacto excelente el envio rapido y todo a la perfecccion los peptidos una maravilla
Excelente servicio, muy amables, muy el paquete llegó en tiempo y forma, muy bien empaquetado y producto de calidad.
Es la 3a vez que compro y todo va bien ! Los empaques de lujo y el seguimiento igual ! Éxitos
Excelente servicio, muy seguro, el péptico llegó perfectamente empacado, llego en el tiempo indicado
✉️ We request reviews automatically by email after purchase.
Technical assistant · AI
