Peptide comparison
Both are very short peptides developed by the group of Russian gerontologist Vladimir Khavinson, who proposes that certain peptides of two to four amino acids can modulate gene expression in specific tissues. Epitalon is associated with the pineal gland and telomerase; Pinealon with nervous tissue.
Compare mechanism, class, receptors and evidence. All compounds are offered with ≥99% purity verified by HPLC and a batch COA.
| Epitalon | Pinealon | |
|---|---|---|
| Sequence | Ala-Glu-Asp-Gly (tetrapeptide) | Glu-Asp-Arg (tripeptide) |
| Origin | Synthetic analogue based on pineal gland extracts (epithalamin) | Synthetic peptide from the same bioregulator school |
| Research focus | Telomerase, melatonin rhythm, ageing | Neuroprotection, oxidative stress in neurons |
| Hypothesised action | Regulation of gene expression | Regulation of gene expression |
| Main models | Cell cultures and animals; small clinical studies | Cell cultures and animals |
| Sources of evidence | Concentrated in a few research groups | Concentrated in a few research groups |
Epitalon is the best known of the short bioregulators. It was developed as a synthetic version of the activity attributed to pineal gland extracts, and its research has focused on telomerase and telomere length, melatonin rhythms and ageing markers in animal models. Pinealon, a tripeptide, has been studied mainly for protective effects in nerve cells under oxidative stress.
They share both the hypothesis (that such small peptides enter the cell and modulate genes) and the main limitation of their evidence: it comes largely from the same research group and has been little replicated independently. That is why their results are best read as experimental findings that need confirmation.
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It is the term used by Vladimir Khavinson's school for short peptides (two to four amino acids) to which it attributes the ability to modulate gene expression in specific tissues.
No. Epitalon is a tetrapeptide (Ala-Glu-Asp-Gly) associated with the pineal gland and telomerase; Pinealon is a tripeptide (Glu-Asp-Arg) studied for neuroprotection.
It is mostly preclinical and comes from a few research groups. Independent studies to confirm it are lacking.
Purity ≥99% verificada por HPLC and batch COA.
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