Peptide comparison
They share the four substitutions that protect the GHRH(1-29) fragment from breakdown. The only thing separating them is DAC, a complex that binds the molecule to blood albumin. That addition changes the half-life from minutes to days and, with it, the kind of signal the pituitary receives.
Compare mechanism, class, receptors and evidence. All compounds are offered with ≥99% purity verified by HPLC and a batch COA.
| CJC-1295 with DAC | CJC-1295 without DAC (Mod GRF 1-29) | |
|---|---|---|
| Base | GHRH(1-29) with 4 substitutions | GHRH(1-29) with 4 substitutions |
| Addition | DAC: maleimide group with a spacer | None |
| Albumin binding | Covalent, to a cysteine on albumin | No |
| Described half-life | Several days | On the order of 30 minutes |
| Type of signal | Sustained | Pulsatile, similar to natural GHRH |
| Typical use in studies | Prolonged exposure with few administrations | Combined with a GHRP to amplify pulses |
The starting sequence is the same: the active fragment of GHRH with substitutions at positions 2, 8, 15 and 27 that make it resistant to DPP-4 and other enzymes. DAC (Drug Affinity Complex) adds a reactive group that, once in circulation, forms a covalent bond with albumin. Bound to that protein, the peptide escapes renal filtration and is released slowly.
The consequence is not only about duration. Without DAC, the signal arrives and disappears quickly, much as the pituitary receives natural GHRH. With DAC, the receptor is exposed in a sustained way. That is why they are not interchangeable in an experimental design, and why the product name should always state which one it is: plain “CJC-1295” is not enough to know what is being studied.
💡 Want the complete scientific foundations? See the Peptide guide or the Certification in Peptide Science.
Drug Affinity Complex: a chemical group with a spacer that covalently binds the peptide to blood albumin and extends its half-life from minutes to several days.
Yes. Both names refer to the GHRH(1-29) fragment with four substitutions and without the affinity complex.
Because they act on different receptors that reinforce each other: the GHRH analogue increases the hormone released in each pulse and the GHRP amplifies the pulse. The combination is studied as a way to strengthen pulsatile secretion.
Purity ≥99% verificada por HPLC and batch COA.
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