Every time a cell copies its DNA, the ends of the chromosomes are not fully replicated and the telomeres lose a small stretch. When they become too short, the cell stops dividing (senescence). That is why telomere length is studied as one of the markers of cellular ageing.
Telomerase adds repeats to telomeres and compensates for that wear. It is active in stem and germ cells and almost switched off in most adult cells. It is also reactivated in many tumour cells, which calls for caution when interpreting any strategy that stimulates it.
In the peptide field, Epitalon (Ala-Glu-Asp-Gly), developed in Vladimir Khavinson's Russian school of bioregulators, has been studied for its relationship with telomerase activity, mainly in cell cultures and animal models.
Most of the evidence on peptides and telomeres is preclinical and comes from a few research groups. It is a good example of an area where experimental findings should be kept apart from proven benefit.
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Learn it in depth at the Peptide University
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Definition for educational and scientific purposes. It is not medical advice or a recommendation for use. NeoPeptidos products are sold labelled for research use only (RUO).