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11
Sermorelin
Somatotropic · GHRH- Class: GHRH analog corresponding to the active fragment GHRH(1-29).
- Target / mechanism: GHRH receptor; GH stimulation with a profile close to physiological.
- Key pharmacology: short-acting, respectful of pulsatility; long clinical history.
- Context: the "classic" among GHRH analogs.
12
PT-141 (Bremelanotide)
Melanocortin · MC4R- Class: melanocortin agonist with a preference for MC4R.
- Target / mechanism: MC4R in the CNS, a pathway involved in sexual response (central, not vascular, mechanism).
- Key pharmacology: derived from melanotan; formal clinical development in desire disorders.
- Context: an example of subtype selectivity within the melanocortins.
13
Melanotan-2
Melanocortin · pigmentation- Class: poorly selective melanocortin agonist (several subtypes).
- Target / mechanism: melanocortin receptors, with MC1R central to melanogenesis (pigmentation).
- Key pharmacology: potent inducer of pigmentation; broad effect profile because of its low selectivity.
- Context: research on pigmentation; requires dermatological monitoring.
14
Semax
Neuromodulator- Class: heptapeptide derived from ACTH(4-10) with a stabilizing extension.
- Target / mechanism: modulation of neurotrophic factors (BDNF) and the dopaminergic system; neuroprotection.
- Key pharmacology: studied by the intranasal route for CNS access.
- Context: cognition and neuroprotection; extensive research in its region of origin.
15
Epitalon
Longevity- Class: tetrapeptide (Ala-Glu-Asp-Gly) derived from pineal epithalamin.
- Target / mechanism: relationship with telomerase activity and telomere length; modulation of the melatonin rhythm.
- Key pharmacology: short peptide; mostly preclinical and early-phase research.
- Context: the reference of the longevity block, together with MOTS-c and SS-31.
Catalogue compounds mentioned in this lesson
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