ACTH(4-7) analog · Neuroprotective nootropic
≥99% HPLC per independent batch · the measured value of each batch is on its COA
Refrigerated at 2–8°C in our warehouse · lyophilized and stable during shipping
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If it is lost in transit, at no cost
| Molecular class | ACTH(4-7) analog heptapeptide |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Formula | C37H51N9O10S |
| Molecular weight | 813.93 g/mol |
| CAS | 80714-61-0 |
| Purity | 99% HPLC (guaranteed minimum; the measured value of each batch is on its COA) |
| Storage | -20°C lyophilized · 2-8°C reconstituted |
You can buy Semax in Mexico for research at NeoPeptidos. Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro), an analog of the ACTH(4-7) fragment, developed at the Institute of Molecular Biology in Moscow. Unlike full ACTH, it lacks hormonal effects and has been investigated exclusively for its nootropic and neuroprotective properties.
See the full technical sheet: mechanism, evidence and regulatory status ↓
The following research areas have been studied in preclinical models (in vitro and in vivo in animals). This information is for scientific reference only.
Chemical identity, studied mechanism, quality of the available evidence and regulatory status. Reference material; you do not need to read it to buy.
Resulting concentration depending on the bacteriostatic water you add, and its equivalent in units on a U-100 insulin syringe (100 IU = 1 mL). For this vial, 1 mL is recommended.
| BAC water | Concentration | 250 mcg | 500 mcg | 1000 mcg |
|---|---|---|---|---|
| 1 mL recommended | 10,000 mcg/mL | 2.5 IU (0.03 mL) | 5 IU (0.05 mL) | 10 IU (0.1 mL) |
| 2 mL | 5,000 mcg/mL | 5 IU (0.05 mL) | 10 IU (0.1 mL) | 20 IU (0.2 mL) |
| 3 mL | 3,333.33 mcg/mL | 7.5 IU (0.08 mL) | 15 IU (0.15 mL) | 30 IU (0.3 mL) |
| 5 mL | 2,000 mcg/mL | 12.5 IU (0.13 mL) | 25 IU (0.25 mL) | 50 IU (0.5 mL) |
The reference masses are volumetric calculation values for laboratory work, not an administration schedule. Material for scientific research use only.
Need a different amount? Use the reconstitution calculator or see the full table by vial.
Current status: No regulatory approval in North America or the European Union.
In Mexico, a research peptide is sold as a laboratory reagent (RUO, research use only). It is not a medicine: it has no COFEPRIS sanitary registration for human or veterinary use, it is not dispensed in pharmacies and it does not require a prescription, precisely because it is not sold to be administered to people. RUO labeling is not a commercial technicality; it is the product's regulatory category and defines what can and cannot legally be done with it. Since it is a domestic shipment, the order does not go through customs and is not subject to import procedures.
Semax was developed in Russia and holds a national registration there for certain indications. That registration has no validity in Mexico and implies no recognition by COFEPRIS, the FDA or the EMA.
Regulatory framework reviewed in August 2026. See the full regulatory timeline, with the dates of each FDA decision between 2023 and 2026.
Compounds in the same category, with what sets each one apart and its entry price. Mechanism and cost are compared, not efficacy: there are no human trials that allow them to be ranked by outcome.
| Compound | What sets it apart | From |
|---|---|---|
| Semax este producto | ACTH(4-7) analog · Neuroprotective nootropic | $1,400 ($140/mg) |
| Selank (agotado) | Synthetic heptapeptide · Tuftsin analog | $1,300 ($130/mg) |
| DSIP | Delta Sleep-Inducing Peptide · Neuromodulatory nonapeptide | $1,500 ($150/mg) |
| Cerebrolysin (agotado) | Neuroprotective peptide blend · Porcine extract | $1,300 ($22/mg) |
Comparativa detallada: Semax vs Selank →
Semax is a synthetic heptapeptide derived from the (4-10) fragment of adrenocorticotropic hormone (ACTH), modified by adding the tripeptide Pro-Gly-Pro at the carboxyl end, which gives it resistance to enzymatic degradation without corticotropic hormonal activity.
It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s. It holds a national registration in Russia for certain indications, a fact that should be stated precisely: that registration has no validity in Mexico and implies no recognition by COFEPRIS, the FDA or the EMA.
In terms of chemical identity, it is classified as ACTH(4-7) analog heptapeptide, its CAS number is 80714-61-0, its molecular weight is 813.93 g/mol. These identifiers are what allow the material received to be checked against the batch Certificate of Analysis.
Also known as: ACTH(4-7) analog · neuroprotective nootropic.
The most described pathway is the modulation of brain-derived neurotrophic factor (BDNF) and its receptor TrkB. In animal models, increased BDNF expression in the hippocampus and cortex has been reported after administration.
The structural modification is the key to the design: the ACTH (4-10) fragment retains activity on memory and attention systems described for that domain, but since it lacks the full sequence it does not stimulate the adrenal cortex, separating the neurotropic effect from the hormonal one.
Route used in the studies: Subcutaneous (SC). It is given for documentation purposes, to interpret the literature; it is not an instruction for use.
The literature base comes mostly from Russian groups and is largely published in Russian, which makes independent evaluation difficult and explains why it is rarely cited in Western reviews.
It is not approved by the FDA, the EMA or COFEPRIS. It was placed in Category 2 of the 503A list on September 29, 2023 and reviewed by the FDA advisory committee on July 24, 2026.
Reference: Russian clinical studies (Semax is registered in Russia).
The following lines appear in the preclinical literature. They are listed for scientific reference only: they are not indications, efficacy claims or suggestions for use.
| Compound | Main difference |
|---|---|
| Selank | Derived from tuftsin, not from ACTH. Its literature focuses on modulation of anxiety and the GABAergic system, not on memory and attention. |
The vial is delivered lyophilized, that is, as a dry powder obtained by freeze-drying. In that form it is stable and does not require a cold chain during transport: shipping does not compromise the material. On receipt, it is kept refrigerated between 2 and 8 °C, protected from light.
For the Semax strengths, a reference reconstitution would be: el vial de 10 mg with 1 mL of bacteriostatic water queda a 10 mg/mL. The volume is not fixed — more water gives a more dilute solution with a larger measuring margin; less water concentrates it — and the choice depends on the working protocol.
The diluent is added slowly along the wall of the vial, never directly onto the powder, and left to rest for five to ten minutes. The vial is swirled gently until fully dissolved; shaking it hard subjects the peptide to mechanical stress that can denature it. Once reconstituted, it is kept refrigerated and is not frozen.
Bacteriostatic water contains 0.9% benzyl alcohol as a preservative, which allows multiple draws from the same vial. Plain sterile water has no preservative and is only suitable for immediate use. Signs of degradation to watch for: cloudy solution, visible particles, change in color or odor.
No. It is sold exclusively as a research-use-only (RUO) reagent, labeled as not fit for human consumption. It has no COFEPRIS sanitary registration and no approval from any other agency for human or veterinary use.
Every batch comes with a Certificate of Analysis issued by an independent laboratory, with the HPLC chromatogram, the purity percentage, the batch number and the date of analysis. It is included in the price and you can download it from the product page and from your account.
Shipping is express, 1 to 3 business days depending on the area, with a tracking number, to all 32 states. Since it is a domestic shipment sent from within Mexico, it does not go through customs: there are no holds or import procedures.
Lessons from the free certification that explain Semax and its scientific context:
This compound has no reviews of its own yet. Below you can see what customers say about other products in the catalog: each card shows which one it refers to.
Super bien muy recomedado este laboratorio y llegan en 2 dias 🙏🏻 gracias seguire comprando con ellos
Es mi segunda vez que pido y estoy más que convencido de la excelente calidad y servicio de su equipo... ampliamente recomendables
Empaque excelente, Recibir tu pedido con agua Bac3ml es lo mejor. Entrega en 3 días max.
Me sorprendió la atención y la presentación, llegó a tiempo y muy bien empacado y con su BAC water, absolutamente recomendables y también tiene su guía de preparación y uso que te llega con dos QR en tu paquete
Excelente servicio, muy amables, siempre he recibido mis productos en tiempo y forma, llegan muy bien protegidos y el producto me ha funcionado de maravilla
el servicio desde el primer contacto excelente el envio rapido y todo a la perfecccion los peptidos una maravilla
Excelente servicio, muy amables, muy el paquete llegó en tiempo y forma, muy bien empaquetado y producto de calidad.
Es la 3a vez que compro y todo va bien ! Los empaques de lujo y el seguimiento igual ! Éxitos
Excelente servicio, muy seguro, el péptico llegó perfectamente empacado, llego en el tiempo indicado
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