Peptide University · 4 lessons · 34 min

Module 3: The incretin system and metabolic agonists

Physiology of GLP-1 and GIP, mechanisms of glycemic and weight control, and the logic of single, dual and triple agonists backed by their large trial programs.

This is module 3 of the NeoPeptidos Professional Certification in Peptide Science. It has 4 lessons; each one can be read on its own and all of them are part of the syllabus assessed at the end of the module.

Lesson 1. Incretin physiology

Incretins are gut hormones released in response to food intake that amplify the metabolic response to nutrients. The main ones are GLP-1 (L cells, ileum and colon) and GIP (K cells, duodenum).

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Lesson 2. Pharmacology of agonists: single, dual and triple

The class is organized by the number of co-activated receptors:

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Lesson 3. Evidence and comparison

The strength of this class rests on large clinical trial programs, whose names are worth recognizing:

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Lesson 4. Amylin, the oral route and the next generation

The incretin system is not the only hormonal satiety pathway. Amylin, co-secreted with insulin by the β cell, acts through a different circuit, and its combination with GLP-1 is one of the most active lines of metabolic research.

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Module quiz

When you finish the lessons, take the quiz on the course page. Your progress is saved to your account.

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Educational content for scientific purposes. It distinguishes preclinical from clinical evidence and is not medical advice, diagnosis or a recommendation for use. NeoPeptidos products are sold labelled for research use only (RUO).