Peptide University · 4 lessons · 32 min

Module 1: Biochemical foundations of the peptide

Structure of the amino acid and the peptide bond, acid-base properties (pKa, isoelectric point), levels of structure, structure-activity relationship and synthesis.

This is module 1 of the NeoPeptidos Professional Certification in Peptide Science. It has 4 lessons; each one can be read on its own and all of them are part of the syllabus assessed at the end of the module.

Lesson 1. From amino acid to peptide

A peptide is a polymer of amino acids joined by peptide bonds. It shares its raw material with proteins; the difference is length and, with it, functional specificity.

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Lesson 2. Levels of structure and structure-activity relationship

Biological activity emerges from conformation, which is described in hierarchical levels:

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Lesson 3. Classification and solid-phase synthesis

Peptides are classified by several simultaneous criteria:

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Lesson 4. Chemical modifications: from the natural sequence to the analog

Almost no peptide of pharmacological interest is an untouched natural sequence. Between the endogenous peptide and the analog being studied there is a set of chemical modifications with a specific purpose: resisting enzymes, locking in the active conformation or changing the pharmacokinetics.

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Module quiz

When you finish the lessons, take the quiz on the course page. Your progress is saved to your account.

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Educational content for scientific purposes. It distinguishes preclinical from clinical evidence and is not medical advice, diagnosis or a recommendation for use. NeoPeptidos products are sold labelled for research use only (RUO).