This is module 5 of the NeoPeptidos Professional Certification in Peptide Science. It has 4 lessons; each one can be read on its own and all of them are part of the syllabus assessed at the end of the module.
Lesson 1. Physiology of the GH/IGF-1 axis
Growth hormone (GH) is secreted by the anterior pituitary under dual hypothalamic control: GHRH stimulates it and somatostatin restrains it. A third axis, ghrelin (from the stomach), enhances release through the growth hormone secretagogue receptor GHS-R.
Read the lesson →Lesson 2. GHRH analogs
GHRH analogs act on the GHRH receptor in the pituitary, mimicking the stimulatory hypothalamic signal. They differ mainly in their pharmacokinetics:
Read the lesson →Lesson 3. GHRPs, ghrelin mimetics and synergy
The second class of secretagogues acts on the GHS-R receptor (the ghrelin receptor), through a pathway different from GHRH's:
Read the lesson →Lesson 4. IGF-1, its binding proteins and its variants
Most of the anabolic effects attributed to growth hormone are not produced by GH directly but by IGF-1, synthesized mainly in the liver under GH stimulation. Understanding IGF-1 is understanding half of the somatotropic axis.
Read the lesson →Module quiz
When you finish the lessons, take the quiz on the course page. Your progress is saved to your account.
Go to the quiz →Educational content for scientific purposes. It distinguishes preclinical from clinical evidence and is not medical advice, diagnosis or a recommendation for use. NeoPeptidos products are sold labelled for research use only (RUO).