This is module 2 of the NeoPeptidos Professional Certification in Peptide Science. It has 4 lessons; each one can be read on its own and all of them are part of the syllabus assessed at the end of the module.
Lesson 1. Pharmacodynamics: receptors and signaling
Pharmacodynamics describes the drug's action on the body. In peptides, almost all activity arises from binding to a receptor with a site complementary to the molecule.
Read the lesson →Lesson 2. Pharmacokinetics: ADME and parameters
Pharmacokinetics describes what the body does to the drug through the ADME cycle.
Read the lesson →Lesson 3. Half-life engineering
Prolonging a peptide's t½ is an exercise in molecular design. Main strategies:
Read the lesson →Lesson 4. G protein-coupled receptors: desensitization and tolerance
Most peptides of interest act on G protein-coupled receptors (GPCR). Understanding what happens to the receptor after activation explains phenomena seen in the literature: loss of response with continuous exposure, differences between pulses and sustained exposure, and why the administration pattern matters as much as the dose.
Read the lesson →Module quiz
When you finish the lessons, take the quiz on the course page. Your progress is saved to your account.
Go to the quiz →Educational content for scientific purposes. It distinguishes preclinical from clinical evidence and is not medical advice, diagnosis or a recommendation for use. NeoPeptidos products are sold labelled for research use only (RUO).