Peptide University · 3 lessons · 25 min

Module 11: Chemical stability and peptide formulation

Why and how a peptide degrades (deamidation, oxidation, isomerization, hydrolysis, aggregation), how lyophilization protects it and what role each excipient plays.

This is module 11 of the NeoPeptidos Professional Certification in Peptide Science. It has 3 lessons; each one can be read on its own and all of them are part of the syllabus assessed at the end of the module.

Lesson 1. Chemical degradation: the weak points of the sequence

A peptide does not «go bad» at random: it degrades through specific chemical reactions that occur at specific residues. Knowing them makes it possible to predict which peptides are fragile and why they are stored the way they are.

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Lesson 2. Physical degradation: aggregation and adsorption

A peptide can lose activity without any covalent bond breaking: it is enough for its physical state to change.

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Lesson 3. Lyophilization and excipients

Lyophilization is the reason a peptide can travel at room temperature and keep for years. Understanding the process explains what a vial actually contains.

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Module quiz

When you finish the lessons, take the quiz on the course page. Your progress is saved to your account.

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Educational content for scientific purposes. It distinguishes preclinical from clinical evidence and is not medical advice, diagnosis or a recommendation for use. NeoPeptidos products are sold labelled for research use only (RUO).