Scientific glossary · Evidence and regulation

What is a clinical trial registry such as ClinicalTrials.gov for?

A clinical trial registry is a public database where studies are listed before they start, with their design and objectives. It shows what is being researched and helps detect unpublished results.

Each registered trial receives an identifier (on ClinicalTrials.gov, a code beginning with NCT) and its design becomes public: which compound is being studied, in whom, against which comparator and what the primary outcome will be. In many cases the results are also posted, even if they never reach a journal.

Prior registration tackles two problems. Publication bias, because it is known which studies started even if their results are not disseminated. And after-the-fact changes of objectives, because the primary outcome was fixed before the data were known.

For a specific compound, searching a registry is the fastest way to know whether there are human trials, what phase they are in and who sponsors them.

Why it matters in peptide research

If a compound is presented with a lot of evidence but no registered trial appears, that evidence is most likely preclinical or anecdotal.

Related terms

Definition for educational and scientific purposes. It is not medical advice or a recommendation for use. NeoPeptidos products are sold labelled for research use only (RUO).