Scientific glossary · Analytical quality

What is a certificate of analysis (COA) and how do you read it?

A certificate of analysis is the document that reports the test results of a specific batch: identity, purity and other parameters, with the methods used and the laboratory that performed them.

A useful COA unambiguously identifies the material it refers to: compound name, batch number, date of analysis and issuing laboratory. It then lists each test with its specification and result: appearance, identity by mass spectrometry, purity by HPLC and, when measured, peptide content, water or counter-ion.

When reading it, three things are worth checking. That the batch on the certificate matches the batch on the vial. That the supporting evidence is included (the chromatogram and the mass spectrum), not just a table of percentages. And that the measured mass matches the compound's theoretical mass.

Be wary of generic certificates with no batch or date, reused for several products, or with “round” results and no graph to support them.

Why it matters in peptide research

The COA turns a sales claim (“99% pure”) into verifiable data. That is why every batch should be searchable by its number and linked from the product page.

Related terms

Learn it in depth at the Peptide University

Definition for educational and scientific purposes. It is not medical advice or a recommendation for use. NeoPeptidos products are sold labelled for research use only (RUO).