Reading time: ~2 min · Part of the free certification in peptide science
BPC-157 ("Body Protection Compound") is a 15-amino-acid pentadecapeptide derived from a partial sequence of a protein in gastric juice. It is intensively investigated in soft tissue repair models.
The mechanisms proposed in the preclinical literature include:
- Angiogenesis: promotion of vessel formation, involving the VEGF pathway and the VEGFR2 receptor, key to supplying blood to tissue under repair.
- Nitric oxide (NO) pathway: modulation of the NO synthase axis, related to vascular tone and cytoprotection.
- Interaction with the gut-brain axis: modulation of dopaminergic and serotonergic systems has been described in models.
- Fibroblast migration and growth factor expression in tendon, ligament, muscle and mucosa.
A distinctive pharmaceutical trait is its relative stability in gastric medium, uncommon among peptides, which sets it apart from most in terms of study routes. It is important to frame the evidence: it is mostly preclinical, and its translation to humans is an active area of research.
Catalogue compounds mentioned in this lesson
Take the module 4 quiz and earn your certificate
The certification is free: read the lessons, pass each module quiz and the final exam, and download your PDF certificate with a verifiable ID.
Go to the quiz →Educational content for scientific purposes. It distinguishes preclinical from clinical evidence and is not medical advice, diagnosis or a recommendation for use. NeoPeptidos products are sold labelled for research use only (RUO).