Reading time: ~2 min · Part of the free certification in peptide science
The error that ruins the most peptides is not a one-off but cumulative storage. Three enemies: temperature, light and freeze-thaw cycles.
| State | Storage | Approximate stability |
|---|---|---|
| Lyophilized (sealed, long term) | Freezer -20 °C, protected from light | Months to years |
| Lyophilized (short term / transit) | Room temperature, dry and dark | Weeks to months (the powder is stable) |
| Reconstituted | Refrigerator 2-8 °C, not frozen | Days to a few weeks depending on the compound |
Critical points: (1) the lyophilizate is remarkably stable — shipping at room temperature does not compromise it, because the dry powder tolerates weeks or months; (2) once reconstituted it is not frozen, because ice crystals damage the molecule; (3) each freeze-thaw cycle degrades the material somewhat, so it is advisable to aliquot before freezing and thaw only what is needed.
Cold, dry and dark. Aliquot to avoid repeated cycles. Always label with compound, concentration and date: an unlabeled vial is a lost vial. The full storage guide details specific cases.
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